SMAD9

Also known as MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B, SMAD8/9, SMAD family member 9

Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the SMAD9 gene.

Gene data

SMAD9

Name: SMAD family member 9
Type: protein-coding
Position: 36,844,831–36,920,887 (−)
Aliases: MADH6, MADH9, PPH2, SMAD8, SMAD8/9, SMAD8A, SMAD8B
Ensembl: ENSG00000120693
RefSeq RNA: NM_001127217.3, NM_001378621.1, NM_001445970.1, NM_001445972.1, NM_001445974.1
RefSeq protein: NP_001120689.1, NP_001365550.1, NP_001432899.1, NP_001432901.1, NP_001432903.1

The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].

Pathways

TGF-beta signaling pathway - Homo sapiens (human)Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)Signal Transduction Signaling by BMP Signaling by TGFB family members Differentiation of white and brown adipocyte BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation ESC Pluripotency Pathways Neovascularisation processes Osteoblast differentiation

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 21198
exact match: identifiers.org/ncbigene/4093
genomic end: 37494902
genomic start: 37418968
cytogenetic location: 13q13.3

Sources (3)

via Wikidata · CC0

~2 min read

Article

2 sections

Contents

Nomenclature
References

Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the SMAD9 gene.

SMAD9, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members, SMAD9 is involved in cell signalling. When a bone morphogenetic protein binds to a receptor (BMP type 1 receptor kinase) it causes SMAD9 to interact with SMAD anchor for receptor activation (SARA).The binding of ligands causes the phosphorylation of the SMAD9 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD9 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. There are two isoforms of the protein. Confusingly, it is also sometimes referred to as SMAD8 in the literature.