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GeneQ18040936· pop 5· linked from 87 articles

POLE3

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Also known as CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

Gene data

POLE3
Name
DNA polymerase epsilon 3, accessory subunit
Type
protein-coding
Position
113,407,232–113,410,723 (−)
Aliases
CHARAC17, CHRAC17, CHRAC2, YBL1, p17
Ensembl
ENSG00000148229
RefSeq RNA
NM_001278255.1, NM_001433719.1, NM_017443.5
RefSeq protein
NP_001265184.1, NP_001420648.1, NP_059139.3

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004].

Gene Ontology

Pathways

DNA replication - Homo sapiens (human)Base excision repair - Homo sapiens (human)Nucleotide excision repair - Homo sapiens (human)Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateRecognition of DNA damage by PCNA-containing replication complexResolution of AP sites via the multiple-nucleotide patch replacement pathwayCell CycleMitotic G1 phase and G1/S transitionPCNA-Dependent Long Patch Base Excision RepairTermination of translesion DNA synthesis

via MyGene.info

Gene · Ensembl

DNA polymerase epsilon 3, accessory subunit

Symbol
POLE3
Biotype
Protein coding
Organism
Homo sapiens
Location
9:113,407,232-113,410,723
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
9694
genomic start
113407235
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/54107
chromosome
human chromosome 9
genomic end
113410675
cytogenetic location
9q32
expressed in
bone marrow
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections
Contents
  • Interactions
  • References
  • Further reading

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]

Excerpted from Wikipedia’s “POLE3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0