SMG7
Sign in to saveAlso known as C1orf16, EST1C, SGA56M, SMG7, nonsense mediated mRNA decay factor, SMG7 nonsense mediated mRNA decay factor
Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.
Gene data
SMG7- Name
- SMG7 nonsense mediated mRNA decay factor
- Type
- protein-coding
- Position
- 183,471,871–183,598,246 (+)
- Aliases
- C1orf16, EST1C, SGA56M
- Ensembl
- ENSG00000116698
- RefSeq RNA
- NM_001174061.2, NM_001331007.2, NM_001350219.2, NM_001350220.2, NM_001350221.2
- RefSeq protein
- NP_001167532.1, NP_001317936.1, NP_001337148.1, NP_001337149.1, NP_001337150.1
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SMG7 nonsense mediated mRNA decay factor
- Symbol
- SMG7
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:183,471,871-183,598,246
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.
== References ==
Excerpted from Wikipedia’s “SMG7” article, available under the CC BY-SA 4.0 licence.