SMC6
Sign in to saveAlso known as SMC-6, SMC6L1, hSMC6, structural maintenance of chromosomes 6
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.
Gene data
SMC6- Name
- structural maintenance of chromosomes 6
- Type
- protein-coding
- Position
- 17,662,940–17,800,242 (−)
- Aliases
- SMC-6, SMC6L1, hSMC6
- Ensembl
- ENSG00000163029
- RefSeq RNA
- NM_001142286.2, NM_024624.6, XM_011533107.4, XM_011533108.4, XM_017004913.3
- RefSeq protein
- NP_001135758.1, NP_078900.1, XP_011531409.1, XP_011531410.1, XP_016860402.1
Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
structural maintenance of chromosomes 6
- Symbol
- SMC6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:17,662,940-17,800,242
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~3 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Nse subunits
- Localization
- Role in recombination and meiosis
- References
- Further reading
Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene.
== Structure == The SMC6 was discovered first in fission yeast as RAD18 (SMC6). It forms a heterodimeric complex with Spr18 (SMC5) protein. In yeast, SMC5/6 complex has sub-units which consists of SMC5, SMC6 and six nonstructural maintenance of chromosomes (NSE) proteins. Nse1-Nse3-Nse4 subunits bridge the Smc5 head Smc6 and allow the binding of DNA.
Excerpted from Wikipedia’s “SMC6” article, available under the CC BY-SA 4.0 licence.