SNX1

Also known as HsT17379, VPS5, sorting nexin 1

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

Gene data

SNX1

Name: sorting nexin 1
Type: protein-coding
Position: 64,094,123–64,146,571 (+)
Aliases: HsT17379, VPS5
Ensembl: ENSG00000028528
RefSeq RNA: NM_001242933.2, NM_003099.5, NM_148955.4, NM_152826.2
RefSeq protein: NP_001229862.1, NP_003090.2, NP_683758.1

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].

Pathways

Endocytosis - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

sorting nexin 1

Symbol: SNX1
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:64,094,123-64,146,571
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: PDB 2i4k EBI.png

Show 7 more facts

HomoloGene ID: 99716
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6642
genomic end: 64438289
genomic start: 64386322
chromosome: human chromosome 15
cytogenetic location: 15q22.31

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

== Function ==

Excerpted from Wikipedia’s “SNX1” article, available under the CC BY-SA 4.0 licence.