SNX5
Sign in to saveAlso known as sorting nexin 5
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
Gene data
SNX5- Name
- sorting nexin 5
- Type
- protein-coding
- Position
- 17,941,597–17,969,022 (−)
- Ensembl
- ENSG00000089006
- RefSeq RNA
- NM_001282454.2, NM_014426.4, NM_152227.3
- RefSeq protein
- NP_001269383.1, NP_055241.1, NP_689413.1
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sorting nexin 5
- Symbol
- SNX5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:17,941,597-17,969,022
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 40944
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27131
- genomic end
- 17949623
- genomic start
- 17922241
- chromosome
- human chromosome 20
- cytogenetic location
- 20p11.23
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.
Excerpted from Wikipedia’s “SNX5” article, available under the CC BY-SA 4.0 licence.