SNX9
Sign in to saveAlso known as SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Gene data
SNX9- Name
- sorting nexin 9
- Type
- protein-coding
- Aliases
- SDP1, SH3PX1, SH3PXD3A, WISP
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013].
via MyGene.info
Wikidata facts
- Image
- Protein SNX9 PDB 2RAI.png
Show 5 more facts
- HomoloGene ID
- 49454
- exact match
- identifiers.org/ncbigene/51429
- genomic end
- 158366109
- genomic start
- 158244296
- cytogenetic location
- 6q25.3
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.