Structure via PubChem · Public domain (PubChem)
sorbinil
Sign in to saveAlso known as CP-45634, sorbinol, (S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione
Sorbinil (INN) is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy. Aldose reductase is an enzyme present in lens and brain that removes excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. Sorbinil reduced sorbitol accumulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25 mg/kg sorb
Chemical data
- Formula
- C11H9FN2O3
- Molecular weight
- 236.2 g/mol
- IUPAC name
- (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
- SMILES
- C1COC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F
- InChIKey
- LXANPKRCLVQAOG-NSHDSACASA-N
- XLogP
- 0.7
- Polar surface area
- 67.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- diabetic retinopathy
via ChEMBL · EBI
Wikidata facts
- Mass
- 236.06
Show 5 more facts
- chemical formula
- C₁₁H₉FN₂O₃
- canonical SMILES
- C1COC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F
- isomeric SMILES
- C1COC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F
- World Health Organisation international non-proprietary name
- sorbinil
- Commons category
- Sorbinil
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Sorbinil (INN) is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy. Aldose reductase is an enzyme present in lens and brain that removes excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. Sorbinil reduced sorbitol accumulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25 mg/kg sorbinil.
==References==
Excerpted from Wikipedia’s “sorbinil” article, available under the CC BY-SA 4.0 licence.