metformin
Sign in to saveMetformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication. It has been shown to inhibit inflammation, and is not associated with weight gain. Metformin is taken by mouth.
AI overview
Metformin is a widely prescribed oral medication primarily used to treat type 2 diabetes, especially in people who are overweight, and it's also used for other conditions like polycystic ovary syndrome. It matters because it helps control blood sugar, doesn't cause weight gain, and has anti-inflammatory effects, making it a foundational treatment in diabetes management.
AI-generated from the Wikipedia summary — may contain errors.
Key facts
- Drug.ChemSpiderID2
- 13583
- Drug.UNII
- 9100L32L2N
- Drug.image
- Metformin.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Metformin-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.pronounce
- ,
- Drug.tradename
- Glucophage, others
- Drug.MedlinePlus
- a696005
- Drug.DailyMedID
- Metformin
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.class
Article
41 sectionsContents
- Medical uses
- Type 2 diabetes
- Efficacy
- Polycystic ovary syndrome
- Diabetes and pregnancy
- Weight change
- Use with insulin
- Contraindications
- Adverse effects
- Gastrointestinal
- Vitamin B<sub>12</sub>
- Lactic acidosis
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Impurities
- History
- Society and culture
- Environmental impact
- Formulations
- Combination with other medications
- [[Thiazolidinedione]]s (TZDs; glitazones)
- Rosiglitazone
- Pioglitazone
- DPP-4 inhibitors
- SGLT2 inhibitors
- Sulfonylureas
- Meglitinide
- Triple combination
- Research
- Aging and life extension
- Cancer
- COVID-19
- Neurological and neurodegenerative disorders
- Derivatives
- References
- Further reading
- External links
Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication. It has been shown to inhibit inflammation, and is not associated with weight gain. Metformin is taken by mouth.
Metformin is generally well tolerated. Common adverse effects include diarrhea, nausea, and abdominal pain. It has a small risk of causing low blood sugar. High blood lactic acid level (acidosis) is a concern if the medication is used in overly large doses or prescribed to people with severe kidney problems.
Gallery (11)
Connections
Categories
Anti-aging substancesAnti-diabetic drugsAnti-inflammatory agentsBiguanidesChemical articles with multiple CAS registry numbersChemical articles with multiple ChEBIsChemical articles with multiple PubChem CIDsChemicals using indexlabelsDrugs developed by Boehringer IngelheimDrugs developed by MerckDrugs with non-standard legal statusDrugs with unknown mechanisms of action