STAT3

Name

signal transducer and activator of transcription 3

Type

protein-coding

Position

42,313,322–42,388,574 (−)

Aliases

ADMIO, ADMIO1, APRF, HIES

Ensembl

ENSG00000168610

RefSeq RNA

NM_001369512.1, NM_001369513.1, NM_001369514.1, NM_001369516.1, NM_001369517.1

RefSeq protein

NP_001356441.1, NP_001356442.1, NP_001356443.1, NP_001356445.1, NP_001356446.1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 3

Symbol

STAT3

Biotype

Protein coding

Organism

Homo sapiens

Location

17:42,313,322-42,388,574

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Stat3 structure.png

via Wikidata · CC0