File:Lovastatin.svg · Wikimedia Commons · See Wikimedia Commons
statin
Sign in to saveAlso known as HMG-CoA reductase inhibitors, hydroxymethylglutaryl-CoA reductase inhibitors, Statins, Statins, HMG-CoA, Inhibitors, HMG-CoA Reductase, Inhibitors, Hydroxymethylglutaryl-Coenzyme A, Inhibitors, Hydroxymethylglutaryl-CoA
Statins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are typically prescribed to people who are at high risk of cardiovascular disease.
Key facts
- Drug class.Image
- Lovastatin.svg
- Drug class.ImageClass
- skin-invert-image
- Drug class.Alt
- Lovastatin
- Drug class.Caption
- Lovastatin, a compound isolated from Aspergillus terreus, is the first statin to be marketed.
- Drug class.Use
- High cholesterol
- Drug class.Biological_target
- HMG-CoA reductase
- Drug class.ATC_prefix
- C10AA
- Drug class.MeshID
- D019161
- Drug class.synonyms
- HMG-CoA reductase inhibitors
via Wikipedia infobox
Research
75,248 papers- Statin-Associated Side Effects.Journal of the American College of Cardiology · 2016
- Statin-induced myopathies.Pharmacological reports : PR · 2011
- Structural mechanism for statin inhibition of HMG-CoA reductase.Science (New York, N.Y.) · 2001
- Statin Use and Hyperglycemia: Do Statins Cause Diabetes?Current atherosclerosis reports · 2024
- [Statin intolerance and statin-associated muscular pain].Herz · 2022
via PubMed
~36 min read
Encyclopedic overview
26 sectionsContents
- Medical uses
- Primary prevention
- Secondary prevention
- Comparative effectiveness
- Women and children
- Familial hypercholesterolemia
- Contrast-induced nephropathy
- Chronic kidney disease
- Asthma
- Adverse effects
- Cognitive effects
- Muscles
- Diabetes
- Cancer
- Drug interactions
- Osteoporosis and fractures
- Mechanism of action
- Inhibiting cholesterol synthesis
- Increasing LDL uptake
- Decreasing of specific protein prenylation
- Other effects
- Available forms
- History
- Research
- References
- External links
Statins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are typically prescribed to people who are at high risk of cardiovascular disease.
Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and coronary heart disease via the mechanisms described by the lipid hypothesis. As lipid-lowering medications, statins are effective in lowering apolipoprotein B and LDL cholesterol; they are widely used for primary prevention in people at high risk of cardiovascular disease, as well as in secondary prevention for those who have developed cardiovascular disease.
Excerpted from Wikipedia’s “statin” article, available under the CC BY-SA 4.0 licence.