statin
Sign in to saveStatins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are typically prescribed to people who are at high risk of cardiovascular disease.
Key facts
- Drug class.Image
- Lovastatin.svg
- Drug class.ImageClass
- skin-invert-image
- Drug class.Alt
- Lovastatin
- Drug class.Caption
- Lovastatin, a compound isolated from Aspergillus terreus, is the first statin to be marketed.
- Drug class.Use
- High cholesterol
- Drug class.Biological_target
- HMG-CoA reductase
- Drug class.ATC_prefix
- C10AA
- Drug class.MeshID
- D019161
- Drug class.synonyms
- HMG-CoA reductase inhibitors
via Wikipedia infobox
Article
26 sectionsContents
- Medical uses
- Primary prevention
- Secondary prevention
- Comparative effectiveness
- Women and children
- Familial hypercholesterolemia
- Contrast-induced nephropathy
- Chronic kidney disease
- Asthma
- Adverse effects
- Cognitive effects
- Muscles
- Diabetes
- Cancer
- Drug interactions
- Osteoporosis and fractures
- Mechanism of action
- Inhibiting cholesterol synthesis
- Increasing LDL uptake
- Decreasing of specific protein prenylation
- Other effects
- Available forms
- History
- Research
- References
- External links
Statins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are typically prescribed to people who are at high risk of cardiovascular disease.
Low-density lipoprotein (LDL) carriers of cholesterol play a key role in the development of atherosclerosis and coronary heart disease via the mechanisms described by the lipid hypothesis. As lipid-lowering medications, statins are effective in lowering apolipoprotein B and LDL cholesterol; they are widely used for primary prevention in people at high risk of cardiovascular disease, as well as in secondary prevention for those who have developed cardiovascular disease.