Structure via PubChem · Public domain (PubChem)
gemfibrozil
Sign in to saveAlso known as 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid
Gemfibrozil, sold under the brand name Lopid among others, is a medication used to treat abnormal blood lipid levels. It is generally less preferred than statins. Use is recommended together with dietary changes and exercise. It is unclear if it changes the risk of heart disease. It is taken by mouth.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 458774072
- Drug.image
- Gemfibrozil.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Lopid, others
- Drug.MedlinePlus
- a686002
- Drug.DailyMedID
- Gemfibrozil
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C10
- Drug.ATC_suffix
- AB04
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- Close to 100%
- Drug.protein_bound
- 95%
- Drug.metabolism
- Liver (CYP3A4)
- Drug.elimination_half life
- 1.5 hours
via Wikipedia infobox
Chemical data
- Formula
- C15H22O3
- Molecular weight
- 250.33 g/mol
- IUPAC name
- 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
- SMILES
- CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
- InChIKey
- HEMJJKBWTPKOJG-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 46.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
2,415 papersvia PubMed
Wikidata facts
- Mass
- 250.157
Show 5 more facts
- chemical formula
- C₁₅H₂₂O₃
- canonical SMILES
- CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
- World Health Organisation international non-proprietary name
- gemfibrozil
- defined daily dose
- 1.2
- Commons category
- Gemfibrozil
Sources (8)
via Wikidata · CC0
~4 min read
Article
10 sectionsContents
- Medical uses
- Side effects
- Contraindications
- Drug interactions
- Mechanism of actions
- History
- Environmental data
- References
- Further reading
- External links
Gemfibrozil, sold under the brand name Lopid among others, is a medication used to treat abnormal blood lipid levels. It is generally less preferred than statins. Use is recommended together with dietary changes and exercise. It is unclear if it changes the risk of heart disease. It is taken by mouth.
Common side effects include headache, dizziness, feeling tired, and intestinal upset. Serious side effects may include angioedema, gallstones, liver problems, and muscle breakdown. Use in pregnancy and breastfeeding is of unclear safety. It belongs to the fibrates group of medications and works by decreasing the breakdown of lipids in fat cells.