streptogramins
Sign in to saveclass=skin-invert-image|thumb|Pristinamycin IA, a natural member of the streptogramin B class class=skin-invert-image|thumb|Pristinamycin IIA, a natural member of the streptogramin A class Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.
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class=skin-invert-image|thumb|Pristinamycin IA, a natural member of the streptogramin B class class=skin-invert-image|thumb|Pristinamycin IIA, a natural member of the streptogramin A class Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A (23-membered macrolide) and streptogramin B (depsipeptide). The two groups act synergistically. They are naturally produced in a 3:7 ratio; most formulations keep this ratio.