AI overview
Succinic acid is a type of organic compound with two carboxylic acid groups, found naturally in living organisms and produced industrially for various applications. It matters because it serves as a building block for making plastics, resins, and other chemicals, while also playing a role in cellular energy production.
AI-generated from the Wikipedia summary — may contain errors.
Research
10,279 papers- Role of succinic acid in the regulation of sepsis.International immunopharmacology · 2022
- Bioreactors for succinic acid production processes.Critical reviews in biotechnology · 2019
- Advancing Succinic Acid Biomanufacturing Using the Nonconventional Yeast Yarrowia lipolytica.Journal of agricultural and food chemistry · 2025
- Recent progress on bio-succinic acid production from lignocellulosic biomass.World journal of microbiology & biotechnology · 2021
- [Advances in synthesis of succinic acid using yeast cell factories].Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2024
via PubMed
Article
Succinic acid (/səkˈsɪnɪk/) is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2. In living organisms, succinic acid takes the form of an anion, succinate, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state.
Succinate is generated in mitochondria via the tricarboxylic acid (TCA) cycle. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. As such, succinate links cellular metabolism, especially ATP formation, to the regulation of cellular function.