Structure via PubChem · Public domain (PubChem)
sulfasalazine
Sign in to saveAlso known as Azulfidine®, Salazopyridin®, Salazopyrin®, SAS-500, Salicylazosulfapyridine, Salazosulfapyridine, 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid, 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid
Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first-line treatment in rheumatoid arthritis. It is taken by mouth or can be administered rectally.
Chemical data
- Formula
- C18H14N4O5S
- Molecular weight
- 398.4 g/mol
- IUPAC name
- (3E)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid
- SMILES
- C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N/N=C/3\C=CC(=O)C(=C3)C(=O)O
- InChIKey
- OQANPHBRHBJGNZ-FYJGNVAPSA-N
- XLogP
- 2.3
- Polar surface area
- 146 Ų
- H-bond donors
- 3
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Research
7,370 papers- [Sulfasalazine therapy in spondylarthritis ankylopoietica].Orvosi hetilap · 1989
- Evolution of olsalazine.Scandinavian journal of gastroenterology. Supplement · 1988
- [New and old therapeutic options in ankylosing spondylitis--is there an indication for sulfasalazine?].Zeitschrift fur Rheumatologie · 2002
- [Inhibition of intestinal leukotriene formation as a possible mechanism of action of sulfasalazine, 5-aminosalicylic acid and 4-aminosalicylic acid].Klinische Wochenschrift · 1988
- [Mode of action of sulfasalazine in chronic inflammatory enterocolonic diseases].Therapie · 1992
via PubMed
~6 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Chemistry
- Cost
- Research
- References
{{Drugbox | Verifiedfields = changed | verifiedrevid = 460764435 | image = Sulfasalazine.svg | image_class = skin-invert-image | alt =
| tradename = Azulfidine, Salazopyrin, Sulazine, others | Drugs.com = | MedlinePlus = a682204 | DailyMedID = Sulfasalazine | pregnancy_AU = A | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = Sulfonamides | ATC_prefix = A07 | ATC_suffix = EC01
Excerpted from Wikipedia’s “sulfasalazine” article, available under the CC BY-SA 4.0 licence.