iclaprim

Iclaprim is an antibiotic drug candidate that is active against Gram positive organisms. It is administered intravenously.

Chemical data

Formula: C19H22N4O3
Molecular weight: 354.4 g/mol
IUPAC name: 5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine

via PubChem

Research

95 papers

Iclaprim.Expert opinion on investigational drugs · 2007
Iclaprim: a differentiated option for the treatment of skin and skin structure infections.Expert review of anti-infective therapy · 2018
Iclaprim mesylate displaying a hydrogen-bonded mol-ecular tape.Acta crystallographica. Section E, Crystallographic communications · 2023
Iclaprim, a dihydrofolate reductase inhibitor antibiotic in Phase III of clinical development: a review of its pharmacology, microbiology and clinical efficacy and safety.Future microbiology · 2018
Anti-virulence potential of iclaprim, a novel folic acid synthesis inhibitor, against Staphylococcus aureus.Applied microbiology and biotechnology · 2024

via PubMed

Wikidata facts

Mass: 354.169

Show 3 more facts

chemical formula: C₁₉H₂₂N₄O₃
canonical SMILES: COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC
Commons category: Iclaprim

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History
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Further reading

Iclaprim is an antibiotic drug candidate that is active against Gram positive organisms. It is administered intravenously.

In vitro, iclaprim is active against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), strains of Streptococcus pneumoniae resistant to several common antibiotics, and some Gram-negative bacteria. It is of the diaminopyrimidine dihydrofolate reductase (DHFR)-inhibiting type.