SVIL

Also known as supervillin, MFM10

Supervillin is a protein that in humans is encoded by the SVIL gene.

Gene data

SVIL

Name: supervillin
Type: protein-coding
Position: 29,457,332–29,737,123 (−)
Aliases: MFM10
Ensembl: ENSG00000197321
RefSeq RNA: NM_001323599.2, NM_001323600.1, NM_003174.3, NM_021738.3
RefSeq protein: NP_001310528.1, NP_001310529.1, NP_003165.2, NP_068506.2

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016].