INVS
Sign in to saveAlso known as INV, NPH2, NPHP2, inversin
Inversin is a protein that in humans is encoded by the INVS gene.
In the Vinony graph
Within Vinony's link graph, INVS is referenced by 59 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 5 Wikipedia language editions.
Gene data
INVS- Name
- inversin
- Type
- protein-coding
- Position
- 100,098,378–100,307,195 (+)
- Aliases
- INV, NPH2, NPHP2
- Ensembl
- ENSG00000119509
- RefSeq RNA
- NM_001318381.2, NM_001318382.2, NM_014425.5, NM_183245.2, NR_134606.2
- RefSeq protein
- NP_001305310.1, NP_001305311.1, NP_055240.2
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
inversin
- Symbol
- INVS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:100,098,378-100,307,195
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 7786
- genomic start
- 102861538
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27130
- genomic end
- 100302175
- chromosome
- human chromosome 9
- cytogenetic location
- 9q31.1
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Inversin is a protein that in humans is encoded by the INVS gene.
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Two transcript variants encoding distinct isoforms have been identified for this gene.
Excerpted from Wikipedia’s “INVS” article, available under the CC BY-SA 4.0 licence.