INVS
Sign in to saveAlso known as INV, NPH2, NPHP2, inversin
Inversin is a protein that in humans is encoded by the INVS gene.
Gene data
INVS- Name
- inversin
- Type
- protein-coding
- Aliases
- INV, NPH2, NPHP2
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012].
via MyGene.info
Gene · Ensembl
inversin
- Symbol
- INVS
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:100,098,378-100,307,195
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 7786
- genomic start
- 102861538
- exact match
- identifiers.org/ncbigene/27130
- genomic end
- 100302175
- cytogenetic location
- 9q31.1
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
Inversin is a protein that in humans is encoded by the INVS gene.
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Two transcript variants encoding distinct isoforms have been identified for this gene.