TARBP1
Sign in to saveAlso known as TRM3, TRP-185, TRP185, TAR (HIV-1) RNA binding protein 1, TRMT3
Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene.
In the Vinony graph
Within Vinony's link graph, TARBP1 is referenced by 3 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 5 Wikipedia language editions.
Gene data
TARBP1- Name
- tRNA guanosine 2 -O-methyltransferase TARBP1
- Type
- protein-coding
- Aliases
- TRM3, TRMT3, TRP-185, TRP185
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
tRNA guanosine 2 -O-methyltransferase TARBP1
- Symbol
- TARBP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:234,391,304-234,479,197
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TARBP1 PDB 2ha8.png
Show 7 more facts
- HomoloGene ID
- 38082
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6894
- genomic end
- 234479179
- genomic start
- 234527059
- chromosome
- human chromosome 1
- cytogenetic location
- 1q42.2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene.
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.
Excerpted from Wikipedia’s “TARBP1” article, available under the CC BY-SA 4.0 licence.