Structure via PubChem · Public domain (PubChem)
tazarotene
Sign in to saveAlso known as AGN-190168, Tazorac®, Zorac®, Tazaroteno, Tazarotenum
Tazarotene, sold under the brand name Tazorac, among others, is a third-generation prescription topical retinoid. It is primarily used for the treatment of plaque psoriasis and acne. Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. It is a member of the acetylenic class of retinoids.
In the Vinony graph
Vinony's link graph records 137 inbound references to tazarotene, and connects out to psoriasis, acne and trioxsalen.
It sits within the topics Alkyne derivatives, Anti-acne preparations and Antipsoriatics.
Vinony links it to 15 Wikipedia language editions.
Key facts
- Drug.image
- Tazarotene.png
- Drug.image_class
- skin-invert-image
- Drug.alt
- Skeletal formula of tazarotene
- Drug.width
- 240
- Drug.image2
- Tazarotene-3D-spacefill.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Space-filling model of the tazarotene molecule
- Drug.tradename
- Tazorac, Arazlo, Fabior, others
- Drug.MedlinePlus
- a616052
- Drug.DailyMedID
- Tazarotene
- Drug.routes_of_administration
- Topical
- Drug.ATC_prefix
- D05
- Drug.ATC_suffix
- AX05
- Drug.ATC_supplemental
- (combination with ulobetasol)
- Drug.legal_CA
- Rx-only
- Drug.legal_CA_comment
- /Schedule D
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C21H21NO2S
- Molecular weight
- 351.5 g/mol
- IUPAC name
- ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
- SMILES
- CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
- InChIKey
- OGQICQVSFDPSEI-UHFFFAOYSA-N
- XLogP
- 4.9
- Polar surface area
- 64.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1997
- Admin. routes
- topical
- Indications
- acne, psoriasis, skin disease, Cutaneous T-cell lymphoma
via ChEMBL · EBI
Research
752 papers- Tazarotene.2006
- Tazarotene.Drugs · 1998
- Tazarotene 0.045% Lotion: A Novel Retinoid Formulation.The Annals of pharmacotherapy · 2022
- GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing.Journal of nanobiotechnology · 2022
- Pharmacokinetics of tazarotene and acitretin in psoriasis.Expert opinion on drug metabolism & toxicology · 2018
via PubMed
~6 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Available forms
- Contraindications
- Pregnancy
- Adverse effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Synthesis
- Research
- Melanoma
- References
Tazarotene, sold under the brand name Tazorac, among others, is a third-generation prescription topical retinoid. It is primarily used for the treatment of plaque psoriasis and acne. Tazarotene is also used as a therapeutic for photoaged and photodamaged skin. It is a member of the acetylenic class of retinoids.
Tazarotene was approved for medical use in 1997 and is available as a generic medication.
Excerpted from Wikipedia’s “tazarotene” article, available under the CC BY-SA 4.0 licence.
Gallery (3)
Available in 15 languages
- Español
- Français
- 中文
- Italiano
- العربية
- azb
- Bahasa Indonesia
- Odia
- Serbian
- Serbian (Latin)
- Tiếng Việt
- Türkçe
- Welsh
- فارسی
via Wikidata sitelinks · CC0