MMP9
Sign in to saveAlso known as CLG4B, GELB, MANDP2, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B, matrix metallopeptidase 9
Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.
Gene data
MMP9- Name
- matrix metallopeptidase 9
- Type
- protein-coding
- Position
- 46,008,908–46,016,561 (+)
- Aliases
- CLG4B, GELB, MANDP2, MMP-9
- Ensembl
- ENSG00000100985
- RefSeq RNA
- NM_004994.3
- RefSeq protein
- NP_004985.2
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
matrix metallopeptidase 9
- Symbol
- MMP9
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:46,008,869-46,016,561
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein MMP9 PDB 1itv.png
Show 6 more facts
- HomoloGene ID
- 3659
- exact match
- identifiers.org/ncbigene/4318
- genomic end
- 44645200
- genomic start
- 44637547
- cytogenetic location
- 20q13.12
- Commons category
- Gelatinase B (MMP-9)
via Wikidata · CC0
~7 min read
Article
14 sectionsContents
- Function
- Neutrophil action
- Angiogenesis
- Wound repair
- Structure
- Clinical significance
- Arthritis
- Cancer
- Cardiovascular
- Pregnancy-associated malaria (Placental malaria)
- Dry eye
- References
- Further reading
- External links
Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.
== Function ==