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GeneQ18030441· pop 6· linked from 39 articles

SERPINF1

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Also known as EPC-1, OI12, OI6, PEDF, PIG35, serpin family F member 1

Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in vertebrates, this 50 kDa protein is being researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease, and cancer. In humans, pigment epithelium-derived factor is encoded by the SERPINF1 gene.

Gene data

SERPINF1
Name
serpin family F member 1
Type
protein-coding
Position
1,761,958–1,777,627 (+)
Aliases
EPC-1, OI12, OI6, PEDF, PIG35
Ensembl
ENSG00000132386
RefSeq RNA
NM_001329903.2, NM_001329904.2, NM_001329905.2, NM_002615.7, XR_004837577.2
RefSeq protein
NP_001316832.1, NP_001316833.1, NP_001316834.1, NP_002606.3

This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016].

Gene Ontology

Pathways

Wnt signaling pathway - Homo sapiens (human)LncRNA involvement in canonical Wnt signaling and colorectal cancerWnt signalingncRNAs involved in Wnt signaling in hepatocellular carcinomaType I collagen synthesis in the context of Osteogenesis imperfecta

via MyGene.info

Gene · Ensembl

serpin family F member 1

Symbol
SERPINF1
Biotype
Protein coding
Organism
Homo sapiens
Location
17:1,761,958-1,777,627
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Image
Protein SERPINF1 PDB 1imv.png
Show 8 more facts
HomoloGene ID
1965
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/5176
chromosome
human chromosome 17
genomic start
1762029
genomic end
1777565
cytogenetic location
17p13.3
expressed in
gastric mucosa
Sources (6)

via Wikidata · CC0

~7 min read

Encyclopedic overview

9 sections
Contents
  • Discovery
  • Gene
  • Protein
  • Signaling
  • Function
  • Clinical significance
  • Glaucoma and zinc-mediated modulation
  • References
  • External links

Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti-tumorigenic, and neurotrophic functions. Found in vertebrates, this 50 kDa protein is being researched as a therapeutic candidate for treatment of such conditions as choroidal neovascularization, heart disease, and cancer. In humans, pigment epithelium-derived factor is encoded by the SERPINF1 gene.

== Discovery ==

Excerpted from Wikipedia’s “SERPINF1” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0