thymopentin

Thymopentin is a thymic polypeptide derivative which interacts with T cells and acts as an immunostimulant. As such, it was used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in some patients for a brief time under specific treatments. It has also been investigated more recently for applications in the treatment of rheumatoid arthritis, and lung cancer.

In the Vinony graph

Vinony's link graph records 47 inbound references to thymopentin, and connects out to peginterferon alfa-2a, HIV/AIDS and medication.

Vinony files it under Chemical pages without DrugBank identifier, Drugs with no legal status and ECHA InfoCard ID from Wikidata.

Vinony links it to 5 Wikipedia language editions.

Chemical data

Formula: C30H49N9O9
Molecular weight: 679.8 g/mol
IUPAC name: (3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N
InChIKey: PSWFFKRAVBDQEG-YGQNSOCVSA-N
XLogP: -6.4
Polar surface area: 328 Å²
H-bond donors: 11
H-bond acceptors: 12
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Protein
Indications: hepatocellular carcinoma, HIV infection, neoplasm

via ChEMBL · EBI

Research

564 papers

Thymopentin and splenopentin as immunomodulators. Current status.Immunologic research · 1998
Thymopoietin to thymopentin: experimental studies.Survey of immunologic research · 1985
Thymopentin-integrated self-assembling nanoplatform for enhanced photo-immunotherapy in diabetic wound healing.Journal of colloid and interface science · 2025
Thymopentin treatment of rheumatoid arthritis.Arzneimittel-Forschung · 1994
Thymopentin in dermatology.Current problems in dermatology · 1989

via PubMed

Wikidata facts

Mass: 679.365
Has use: medication

Show 4 more facts

chemical formula: C₃₀H₄₉N₉O₉
canonical SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)N
isomeric SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N
subject has role: immunologic adjuvant

Sources (2)

via Wikidata · CC0

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