Thymopoietin
Sign in to saveAlso known as thymopoietin beta, TP alpha, TMPO, TP beta/gamma, thymopoietin-related peptide isoform alpha, LEM domain containing 4, lamina-associated polypeptide 2
Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein.
Protein · UniProt
Lamina-associated polypeptide 2, isoform alpha
- Gene
- TMPO
- Organism
- Homo sapiens (Human)
- Length
- 694 aa
- Molecular mass
- 75,492 Da
- Evidence
- 1: Evidence at protein level
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1
Swiss-Prot (reviewed) · via UniProt
Research
1,067 papers- Thymopoietin to thymopentin: experimental studies.Survey of immunologic research · 1985
- Thymopoietin, a thymic polypeptide, potently interacts at muscle and neuronal nicotinic alpha-bungarotoxin receptors.Molecular neurobiology · 1992
- The Emerging Role of Thymopoietin-Antisense RNA 1 as Long Noncoding RNA in the Pathogenesis of Human Cancers.DNA and cell biology · 2021
- Emerin.The international journal of biochemistry & cell biology · 1999
- Thymopoietin and ubiquitin.Methods in enzymology · 1985
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- cell component
- chromosome
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein.
Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2. LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.
Excerpted from Wikipedia’s “Thymopoietin” article, available under the CC BY-SA 4.0 licence.