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tirilazad
Sign in to saveTirilazad is a drug that has been proposed to treat acute ischaemic stroke. When tested on animal models, tirilazad protects brain tissue, and reduces brain damage. However, the drug fails to treat, and even worsens a stroke when studied on a human being.
Research
453 papers- Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study.JAMA · 1997
- Tirilazad for acute ischaemic stroke.The Cochrane database of systematic reviews · 2001
- Tirilazad for aneurysmal subarachnoid haemorrhage.The Cochrane database of systematic reviews · 2010
- Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage.Neurocritical care · 2009
- Methylated tirilazad may mitigate oligofructose-induced laminitis in horses.Frontiers in microbiology · 2024
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 624.415
Show 5 more facts
- subject has role
- antioxidant
- chemical formula
- C₃₈H₅₂N₆O₂
- canonical SMILES
- CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
- isomeric SMILES
- C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC[C@@]2([C@H]1C(=O)CN5CCN(CC5)C6=NC(=NC(=C6)N7CCCC7)N8CCCC8)C)C
- Commons category
- Tirilazad
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Tirilazad is a drug that has been proposed to treat acute ischaemic stroke. When tested on animal models, tirilazad protects brain tissue, and reduces brain damage. However, the drug fails to treat, and even worsens a stroke when studied on a human being.
Tirilazad is a 21-aminosteroid and belongs to the "Lazaroid" family of agents. The metabolite of tirilazad is called U-89678 [157744-31-5]. Other known lazaroids found in the data base include the following list of agents: U-74389G [153190-29-5], U-74500 [111640-85-8], U-75412E [130590-09-9] & U-87999 [177949-23-4]. The name comes from Lazarus — the biblical figure raised from the dead — because these compounds were thought to “bring cells back to life” after oxidative injury.
Excerpted from Wikipedia’s “tirilazad” article, available under the CC BY-SA 4.0 licence.