TMC8
Sign in to saveAlso known as EV2, EVER2, EVIN2, transmembrane channel like 8
Transmembrane channel-like protein 8 is a protein which in humans is encoded by the TMC8 gene.
Gene data
TMC8- Name
- transmembrane channel like 8
- Type
- protein-coding
- Position
- 78,130,770–78,142,968 (+)
- Aliases
- EV2, EVER2, EVIN2
- Ensembl
- ENSG00000167895
- RefSeq RNA
- NM_152468.5
- RefSeq protein
- NP_689681.2
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
transmembrane channel like 8
- Symbol
- TMC8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:78,130,770-78,142,968
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 45126
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/147138
- genomic end
- 76139049
- genomic start
- 76126851
- chromosome
- human chromosome 17
- cytogenetic location
- 17q25.3
- genetic association
- epidermodysplasia verruciformis
- expressed in
- superficial temporal artery
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Transmembrane channel-like protein 8 is a protein which in humans is encoded by the TMC8 gene.
==Function== The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.
Excerpted from Wikipedia’s “TMC8” article, available under the CC BY-SA 4.0 licence.