Ceruloplasmin
Sign in to saveAlso known as Ferroxidase, ceruloplasmin (ferroxidase), CP
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.
Protein · UniProt
Ceruloplasmin
- Gene
- CP
- Organism
- Homo sapiens (Human)
- Length
- 1,065 aa
- Molecular mass
- 122,219 Da
- Evidence
- 1: Evidence at protein level
Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for …
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
5 registered- RECRUITINGOff Treatment Urinary Copper Excretion in Wilson Disease, Pilot StudyYale University · NCT07301216
- PHASE3COMPLETEDStudy Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary CirrhosisGeorge Brewer · NCT00805805
- COMPLETEDReal World Evidence Study in Subjects With Wilson's DiseaseOrphalan · NCT05783687
- PHASE1/PHASE2UNKNOWNTrial of Novel Oral Zinc Cysteine Preparation in Alzheimer's DiseaseAdeona Pharmaceuticals · NCT01099332
- RECRUITINGThe Correlation Between Ovarian Function and Serum BiomarkersShi Yun · NCT06096766
~6 min read
Encyclopedic overview
10 sectionsContents
- Function
- Active site structure
- Regulation
- Clinical significance
- Deficiency
- Excess
- Reference ranges
- References
- Further reading
- External links
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.
Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.
Excerpted from Wikipedia’s “Ceruloplasmin” article, available under the CC BY-SA 4.0 licence.