Ceruloplasmin

Also known as Ferroxidase, ceruloplasmin (ferroxidase), CP

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.

Protein · UniProt

Ceruloplasmin

Gene: CP
Organism: Homo sapiens (Human)
Length: 1,065 aa
Molecular mass: 122,219 Da
Evidence: 1: Evidence at protein level

Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane (PubMed:16150804). Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin (PubMed:14623105, PubMed:4643313, PubMed:5912351). Provides Cu(2+) ions for …

3D-structureDirect protein sequencingDisulfide bondGlycoproteinMetal-bindingOxidoreductasePhosphoproteinProteomics identification

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

5 registered

RECRUITING
Off Treatment Urinary Copper Excretion in Wilson Disease, Pilot StudyYale University · NCT07301216
PHASE3COMPLETED
Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary CirrhosisGeorge Brewer · NCT00805805
COMPLETED
Real World Evidence Study in Subjects With Wilson's DiseaseOrphalan · NCT05783687
PHASE1/PHASE2UNKNOWN
Trial of Novel Oral Zinc Cysteine Preparation in Alzheimer's DiseaseAdeona Pharmaceuticals · NCT01099332
RECRUITING
The Correlation Between Ovarian Function and Serum BiomarkersShi Yun · NCT06096766

via ClinicalTrials.gov

Wikidata facts

Image: Protein CP PDB 1kcw.png

Show 3 more facts

Commons category: Ceruloplasmin
exact match: purl.uniprot.org/uniprot/P00450
EC enzyme number: 1.16.3.1

Sources (4)

via Wikidata · CC0

~6 min read

Article

10 sections

Contents

Function
Active site structure
Regulation
Clinical significance
Deficiency
Excess
Reference ranges
References
Further reading
External links

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.

Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.