Gene data
TMC8- Name
- transmembrane channel like 8
- Type
- protein-coding
- Position
- 78,130,770–78,142,968 (+)
- Aliases
- EV2, EVER2, EVIN2
- Ensembl
- ENSG00000167895
- RefSeq RNA
- NM_152468.5
- RefSeq protein
- NP_689681.2
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
intracellular zinc ion homeostasisintracellular zinc ion homeostasisregulation of tumor necrosis factor-mediated signaling pathwaynegative regulation of protein-containing complex assemblynegative regulation of protein bindingmonoatomic ion transmembrane transportpositive regulation of apoptotic processnegative regulation of canonical NF-kappaB signal transduction
Molecular function
via MyGene.info
Gene · Ensembl
transmembrane channel like 8
- Symbol
- TMC8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:78,130,770-78,142,968
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 45126
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/147138
- genomic end
- 76139049
- genomic start
- 76126851
- chromosome
- human chromosome 17
- cytogenetic location
- 17q25.3
- genetic association
- epidermodysplasia verruciformis
- expressed in
- superficial temporal artery
via Wikidata · CC0