TP53I3
Sign in to saveAlso known as PIG3, tumor protein p53 inducible protein 3
Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to TP53I3, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
TP53I3- Name
- tumor protein p53 inducible protein 3
- Type
- protein-coding
- Position
- 24,077,433–24,085,861 (−)
- Aliases
- PIG3
- Ensembl
- ENSG00000115129
- RefSeq RNA
- NM_001206802.2, NM_004881.5, NM_147184.4, XM_006712150.3, XM_024453249.2
- RefSeq protein
- NP_001193731.1, NP_004872.2, NP_671713.1, XP_006712213.1, XP_024309017.1
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
tumor protein p53 inducible protein 3
- Symbol
- TP53I3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:24,077,433-24,085,861
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TP53I3 PDB 2j8z.png
Show 7 more facts
- HomoloGene ID
- 36617
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9540
- genomic end
- 24308731
- genomic start
- 24300303
- chromosome
- human chromosome 2
- cytogenetic location
- 2p23.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene.
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.
Excerpted from Wikipedia’s “TP53I3” article, available under the CC BY-SA 4.0 licence.