تی‌پی۶۳

Name

tumor protein p63

Type

protein-coding

Position

189,631,252–189,897,276 (+)

Aliases

AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4

Ensembl

ENSG00000073282

RefSeq RNA

NM_001114978.2, NM_001114979.2, NM_001114980.2, NM_001114981.2, NM_001114982.2

RefSeq protein

NP_001108450.1, NP_001108451.1, NP_001108452.1, NP_001108453.1, NP_001108454.1

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016].

via MyGene.info

Gene · Ensembl

tumor protein p63

Symbol

TP63

Biotype

Protein coding

Organism

Homo sapiens

Location

3:189,631,252-189,897,276

Strand

Forward (+)

Assembly

GRCh38