Transcobalamin 1
Sign in to saveAlso known as Transcobalamin I, transcobalamin I (vitamin B12 binding protein, R binder family), transcobalamin-1, HC, TCI, TC I, haptocorrin, protein R
Haptocorrin (HC) (also known as transcobalamin-1 (TC-1), or cobalophilin) is a transcobalamin glycoprotein that in humans is encoded by the gene. It is essential to protect the acid-sensitive vitamin B12 from degradation while in the stomach. It is also present in the serum where it binds most circulating vitamin B12, rendering it unavailable for uptake by cells (this is conjectured to be a circulating storage function).
Protein · UniProt
Transcobalamin-1
- Gene
- TCN1
- Organism
- Homo sapiens (Human)
- Length
- 433 aa
- Molecular mass
- 48,207 Da
- Evidence
- 1: Evidence at protein level
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
2 registered- COMPLETEDBaby Detect : Genomic Newborn ScreeningCentre Hospitalier Universitaire de Liege · NCT05687474
- ENROLLING_BY_INVITATIONEarly Check: Expanded Screening in NewbornsRTI International · NCT03655223
Wikidata facts
- Instance of
- protein
- Image
- Protein TCN1 PDB 2ckv.png
Show 2 more facts
- found in taxon
- Homo sapiens
- cell component
- extracellular space
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
5 sectionsContents
- Function
- Digestive
- Serum
- References
- Further reading
Haptocorrin (HC) (also known as transcobalamin-1 (TC-1), or cobalophilin) is a transcobalamin glycoprotein that in humans is encoded by the gene. It is essential to protect the acid-sensitive vitamin B12 from degradation while in the stomach. It is also present in the serum where it binds most circulating vitamin B12, rendering it unavailable for uptake by cells (this is conjectured to be a circulating storage function).
== Function ==
Excerpted from Wikipedia’s “Transcobalamin 1” article, available under the CC BY-SA 4.0 licence.