Transferrina
Sign in to saveAlso known as beta-1 metal-binding globulin, epididymis secretory sperm binding protein Li 71p, TF, siderophilin, serotransferrin
Transferrins are glycoproteins found in vertebrates which bind and consequently mediate the transport of iron (Fe) through blood plasma. They are produced in the liver and contain binding sites for two Fe3+ ions. Human transferrin is encoded by the TF gene and produced as a 76 kDa glycoprotein.
Key facts
- Protein family.Symbol
- Transferrin
- Protein family.Name
- Transferrin
- Protein family.Pfam
- PF00405
- Protein family.InterPro
- IPR001156
- Protein family.Prosite
- PDOC00182
- Protein family.SCOP
- 1lcf
via Wikipedia infobox
Protein · UniProt
Serotransferrin
- Gene
- TF
- Organism
- Homo sapiens (Human)
- Length
- 698 aa
- Molecular mass
- 77,064 Da
- Evidence
- 1: Evidence at protein level
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
42 registered- COMPLETEDThe Function of PA, RBP and TRSF in Malnutrition Detecting and Nutritional Status Monitoring for NPC PatientsZhao Chong · NCT03240835
- PHASE3COMPLETEDFERINJECT for Correction of Anaemia in IBD Patients, FER-IBD-CORVifor Pharma · NCT00810030
- NACOMPLETEDIron Supplementation During Pregnancy and Non-Transferrin-Bound Iron (NTBI)Swiss Federal Institute of Technology · NCT01264042
- COMPLETEDIron Replacement in Blood DonorsNational Institutes of Health Clinical Center (CC) · NCT00327067
- PHASE3COMPLETEDComparison of TransMID vs Standard Treatment of Cancerous Brain TumorsNational Institute of Neurological Disorders and Stroke (NINDS) · NCT00088400
- PHASE1RECRUITINGPhase I Study to Assess the Safety and Efficacy of OCU200 for Center-Involved Diabetic Macular Edema (DME)Ocugen · NCT05802329
Wikidata facts
- Instance of
- protein
Show 3 more facts
- exact match
- purl.uniprot.org/uniprot/P02787
- found in taxon
- Homo sapiens
- Commons category
- Transferrin
via Wikidata · CC0
Article · Italiano
La transferrina è la principale proteina di trasporto del ferro nel sangue. Si tratta di una glicoproteina costituita da una singola catena polipeptidica di 78 KDa che possiede due siti di legame per lo ione ferrico (Fe3+), mentre non presenta affinità per lo ione ferroso (Fe2+).
Abstract from DBpedia / Wikipedia · CC BY-SA