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trimeperidine
Sign in to saveAlso known as Promedol
Trimeperidine (trade name Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the early 1950s in the USSR during research into the related drug pethidine.
Chemical data
- Formula
- C17H25NO2
- Molecular weight
- 275.4 g/mol
- IUPAC name
- [(2S,5R)-1,2,5-trimethyl-4-phenylpiperidin-4-yl] propanoate
- SMILES
- CCC(=O)OC1(C[C@@H](N(C[C@H]1C)C)C)C2=CC=CC=C2
- InChIKey
- UVITTYOJFDLOGI-LICQEQMYSA-N
- XLogP
- 3.1
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
275 papers- [Efficiency and safety of a fixed combination of Orphenadrine and Diclofenac for postoperative analgesia in cardiac surgery patients].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
- [Ketoprophen and nefopam combination for postoperative analgesia with minimal use of narcotic analgesics in cardio-surgical patients].Anesteziologiia i reanimatologiia · 2013
- [Analgesia in hemophiliac patients during orthopedic surgery].Terapevticheskii arkhiv · 2014
- Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine.Bulletin of experimental biology and medicine · 2016
- [The use of central acting analgesic nefopam in postoperative analgesia in cardiac surgery patients].Anesteziologiia i reanimatologiia · 2013
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 275.18852904
Show 6 more facts
- chemical formula
- C₁₇H₂₅NO₂
- canonical SMILES
- CCC(=O)OC1(CC(N(CC1C)C)C)C2=CC=CC=C2
- Commons category
- Trimeperidine
- subject has role
- narcotic
- MCN code
- 2933.33.93
- isomeric SMILES
- CCC(=O)OC1(C[C@@H](N(C[C@H]1C)C)C)C2=CC=CC=C2
Sources (1)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Trimeperidine (trade name Promedol) is an opioid analgesic that is an analogue of prodine. It was developed in the early 1950s in the USSR during research into the related drug pethidine.
Trimeperidine has four structural isomers, of which two are active, the γ isomer trimeperidine, and the β isomer isopromedol. It is around half the potency of morphine as an analgesic, and has been widely used for the treatment of pain.
Excerpted from Wikipedia’s “trimeperidine” article, available under the CC BY-SA 4.0 licence.