creatine kinase
Sign in to saveAlso known as creatine phosphokinase, ATP:creatine phosphotransferase, adenosine triphosphate-creatine transphosphorylase, ATP:creatine N-phosphotransferase, phosphocreatine kinase, creatine phosphotransferase, CPK, CK
class of enzymes
Key facts
- Ec no
- 2.7.3.2
- Cas no
- 9001-15-4
- Intenz
- IntEnz view
- Brenda
- BRENDA entry
- Expasy
- NiceZyme view
- Kegg
- KEGG entry
- Metacyc
- metabolic pathway
- Priam
- profile
- Pdb structures
- RCSB PDB PDBe PDBsum
- Gene ontology
- AmiGO / QuickGO
- Pmc
- articles
- Pubmed
- articles
- Ncbi
- proteins
via Wikipedia infobox
Research
45,699 papers- The creatine kinase conundrum: a reappraisal of the association of isotretinoin, creatine kinase, and rhabdomyolysis.International journal of dermatology · 2020
- [Creatine kinase and its isozymes].Rinsho byori. The Japanese journal of clinical pathology · 2001
- Mitochondrial creatine kinase: properties and function.Biochemistry. Biokhimiia · 2001
- Creatine kinase release after catheter-based coronary intervention.Catheterization and cardiovascular diagnosis · 1997
- Creatine kinase isoenzymes: electrophoretic and quantitative measurements.Critical reviews in clinical laboratory sciences · 1981
via PubMed
Wikidata facts
- Image
- 3b6r.png
Show 3 more facts
- Commons category
- Creatine kinases
- EC enzyme number
- 2.7.3.2
via Wikidata · CC0
~7 min read
Article
Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP.
In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the PCr shuttle or circuit. Thus creatine kinase is an important enzyme in such tissues.