TNNI2
Sign in to saveAlso known as AMCD2B, DA2B, FSSV, fsTnI, troponin I2, fast skeletal type, DA2B1
Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene.
Gene data
TNNI2- Name
- troponin I2, fast skeletal type
- Type
- protein-coding
- Position
- 1,838,971–1,841,680 (+)
- Aliases
- AMCD2B, DA2B, DA2B1, FSSV, fsTnI
- Ensembl
- ENSG00000288219
- RefSeq RNA
- NM_001145829.2, NM_001145841.2, NM_003282.4
- RefSeq protein
- NP_001139301.1, NP_001139313.1, NP_003273.1
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
troponin I2, fast skeletal type
- Symbol
- TNNI2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:1,838,971-1,841,680
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNNI2 PDB 1a2x.png
Show 7 more facts
- HomoloGene ID
- 37752
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7136
- genomic end
- 1862910
- genomic start
- 1838981
- chromosome
- human chromosome 11
- cytogenetic location
- 11p15.5
Sources (4)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- Gene evolution
- Tissue distribution
- Protein structure and function
- Posttranslational modifications
- Clinical significance
- Notes
- References
- Further reading
Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene.
The TNNI2 gene is located at 11p15.5 in the human chromosomal genome, encoding the fast twitch skeletal muscle troponin I (fsTnI). fsTnI is a 21.3 kDa protein consisting of 182 amino acids including the first methionine with an isoelectric point (pI) of 8.74. It is the inhibitory subunit of the troponin complex in fast twitch skeletal muscle fibers.
Excerpted from Wikipedia’s “TNNI2” article, available under the CC BY-SA 4.0 licence.