Spastin
Sign in to saveAlso known as spastic paraplegia 4 (autosomal dominant; spastin), spastic paraplegia 4 protein, SPAST
The human gene SPAST codes for the microtubule-severing protein of the same name, commonly known as spastin.
Protein · UniProt
Spastin
- Gene
- SPAST
- Organism
- Homo sapiens (Human)
- Length
- 616 aa
- Molecular mass
- 67,197 Da
- Evidence
- 1: Evidence at protein level
ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated (PubMed:11809724, PubMed:15716377, PubMed:16219033, PubMed:17389232, PubMed:20530212, PubMed:22637577, PubMed:26875866). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Severing activity is not dependent on tubulin acetylation or detyrosination (PubMed:26875866). Microt…
Swiss-Prot (reviewed) · via UniProt
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The human gene SPAST codes for the microtubule-severing protein of the same name, commonly known as spastin.
This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4 (SPG4).