Hamartina
Sign in to saveAlso known as tumor suppressor, tuberous sclerosis 1 protein, TSC1, truncated hemartin, hamartin
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene.
Protein · UniProt
Hamartin
- Gene
- TSC1
- Organism
- Homo sapiens (Human)
- Length
- 1,164 aa
- Molecular mass
- 129,767 Da
- Evidence
- 1: Evidence at protein level
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, Pub…
Swiss-Prot (reviewed) · via UniProt
Research
104 papers- Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway.Autophagy · 2025
- How autophagy controls the intestinal epithelial barrier.Autophagy · 2022
- Emerging dimensions of autophagy in melanoma.Autophagy · 2024
- Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.Circulation · 2024
- Full-coverage regulations of autophagy by ROS: from induction to maturation.Autophagy · 2022
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- P352
- Ivanivka
- found in taxon
- Homo sapiens
via Wikidata · CC0
Article · Português
Proteína 1 de Esclerose Tuberosa, também conhecida como hamartina ou TSC1, é uma proteína humana e gene. Esta proteína da membrana periférica foi implicada como uma supressora de tumores. Também pode estar envolvida no transporte vesicular, em complexo com TSC2. Defeitos neste gene podem causar esclerose tuberosa, devido a um prejuízo funcional do complexo de hamartina-tuberina. Defeitos em TSC1 também podem ser uma causa de .
Abstract from DBpedia / Wikipedia · CC BY-SA