Structure via PubChem · Public domain (PubChem)
vadadustat
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Vadadustat, sold under the brand name Vafseo, is a medication used for the treatment of symptomatic anemia associated with chronic kidney disease. Vadadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor.
Chemical data
- Formula
- C14H11ClN2O4
- Molecular weight
- 306.7 g/mol
- IUPAC name
- 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
- SMILES
- C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
- InChIKey
- JGRXMPYUTJLTKT-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 99.5 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2023
- Admin. routes
- oral
- Indications
- anemia (phenotype), liver disease, chronic kidney disease, anemia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 306.041
Show 3 more facts
- canonical SMILES
- C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
- chemical formula
- C₁₄H₁₁ClN₂O₄
- Commons category
- Vadadustat
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- History
- Society and culture
- Legal status
- Research
- References
- External links
Vadadustat, sold under the brand name Vafseo, is a medication used for the treatment of symptomatic anemia associated with chronic kidney disease. Vadadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor.
The most common side effects include thromboembolic events (problems due to the formation of blood clots in the blood vessels), diarrhea, and hypertension (high blood pressure).
Excerpted from Wikipedia’s “vadadustat” article, available under the CC BY-SA 4.0 licence.