Vitronectina
Sign in to saveAlso known as Vitronectin, serum spreading factor, V75, epibolin, S-protein, VTN, complement S-protein, Serum-spreading factor
proteína de Homo sapiens
Protein · UniProt
Vitronectin
- Gene
- VTN
- Organism
- Homo sapiens (Human)
- Length
- 478 aa
- Molecular mass
- 54,306 Da
- Evidence
- 1: Evidence at protein level
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
Swiss-Prot (reviewed) · via UniProt
Research
6,206 papers- Vitronectin.The international journal of biochemistry & cell biology · 1999
- Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier.Neuron · 2022
- Vitronectin and its receptors.Current opinion in cell biology · 1993
- Vitronectin in atherosclerotic disease.Clinica chimica acta; international journal of clinical chemistry · 2006
- Vitronectin--master controller or micromanager?IUBMB life · 2013
via PubMed
Clinical Trials
22 registered- PHASE3UNKNOWNAn Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various RegimensD'Or Institute for Research and Education · NCT05470803
- PHASE2UNKNOWNImmunogenicity and Safety Study of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adultsin ChinaZhejiang Clover Biopharmaceuticals, Inc. · NCT04954131
- PHASE1COMPLETEDSafety and Immunogenicity Dose-finding Study of Adjuvanted SCB-2020S Vaccine in AdultsClover Biopharmaceuticals AUS Pty · NCT05228314
- PHASE2UNKNOWNEfficacy and Safety of JS016 in Patients With SARS-CoV-2 Infection (COVID-19)Peking Union Medical College Hospital · NCT04931238
- PHASE1COMPLETEDLong-term Follow-up to the Phase 1 Study of Adjuvanted SARS-CoV-2 (SCB 2019) Vaccine for COVID-19.Clover Biopharmaceuticals AUS Pty · NCT04932824
- PHASE1TERMINATEDCORVax12: SARS-CoV-2 Spike (S) Protein Plasmid DNA Vaccine Trial for COVID-19 (SARS-CoV-2)Providence Health & Services · NCT04627675
Wikidata facts
- Instance of
- protein
Show 2 more facts
- biological process
- endocytosis
- found in taxon
- Homo sapiens
via Wikidata · CC0
Article · Español
La vitronectina (VTN o VN) es una glucoproteína de la familia de la hemopexina que se encuentra abundantemente en el suero, la matriz extracelular y el hueso. En los humanos está codificado por el gen VTN. La vitronectina se une a la integrina alfa-V beta-3 (αVβ3), promoviendo la adhesión y la diseminación celular. También inhibe el efecto dañino sobre la membrana de la ruta del complemento citolítico, y se une a varias serpinas (inhibidores de serina proteasa). Es una proteína secretada y existe en forma de cadena única o en forma acoplada, con dos cadenas recortadas unidas por un enlace disulfuro. Se ha especulado que la vitronectina está implicada en la hemostasia y en la malignidad tumoral.
Abstract from DBpedia / Wikipedia · CC BY-SA