xenotransplantation
Sign in to saveAlso known as heterografting, xenograft transplantation, Transplantation, Heterologous
Xenotransplantation (xenos- from the Greek meaning "foreign" or strange), or heterologous transplant, is the transplantation of living cells, tissues or organs from one species to another. Such cells, tissues or organs are called xenografts or xenotransplants. It is contrasted with allotransplantation (from other individual of same species), syngeneic transplantation or isotransplantation (grafts transplanted between two genetically identical individuals of the same species), and autotransplantation (from one part of the body to another in the same person). Xenotransplantation is an artificial
Key facts
- Medical intervention.Caption
- Long axis echocardiography. Representative long axis view echocardiography, four weeks after myocardial infarction (MI), right before CMPC/placebo infusion. Thinning and akinesia of the septal apical wall due to MI can be appreciated.
- Medical intervention.MeshID
- D014183
- Medical intervention.Name
- Xenotransplantation
- Medical intervention.Image
- Xenotransplantation-of-Human-Cardiomyocyte-Progenitor-Cells-Does-Not-Improve-Cardiac-Function-in-a-pone.0143953.s010.ogv
via Wikipedia infobox
Research
39,330 papers- Lung Xenotransplantation.Thoracic surgery clinics · 2023
- Xenotransplantation literature update, September/October 2019.Xenotransplantation · 2019
- The science of xenotransplantation for nephrologists.Current opinion in nephrology and hypertension · 2022
- Microchimerism, PERV and Xenotransplantation.Viruses · 2023
- Clinical xenotransplantation seems close: Ethical issues persist.Artificial organs · 2022
via PubMed
Wikidata facts
- Subclass of
- transplantation
Show 1 more fact
- opposite of
- allotransplantation
Sources (3)
via Wikidata · CC0
~40 min read
Encyclopedic overview
29 sectionsContents
- History
- Non-human kidney to a human
- Non-human heart to a human
- Non-human heart, lungs, and kidneys to a human
- Genetically engineered non-human kidney to a human
- Genetically engineered non-human heart to a human
- Potential uses
- Potential animal organ donors
- Barriers and issues
- Immunologic barriers
- Hyperacute rejection
- Overcoming hyperacute rejection
- Acute vascular rejection
- Overcoming acute vascular rejection
- Accommodation
- Cellular rejection
- Overcoming cellular rejection
- Chronic rejection
- Dysregulated coagulation
- Physiology
- Xenozoonosis
- Porcine endogenous retroviruses
- Ethics
- History of xenotransplantation in ethics
- Informed consent of patient
- Xenotransplantation guidelines in the United States
- See also
- References
- External links
Xenotransplantation (xenos- from the Greek meaning "foreign" or strange), or heterologous transplant, is the transplantation of living cells, tissues or organs from one species to another. Such cells, tissues or organs are called xenografts or xenotransplants. It is contrasted with allotransplantation (from other individual of same species), syngeneic transplantation or isotransplantation (grafts transplanted between two genetically identical individuals of the same species), and autotransplantation (from one part of the body to another in the same person). Xenotransplantation is an artificial method of creating an animal-human chimera, that is, a human with a subset of animal cells. In contrast, an individual where each cell contains genetic material from a human and an animal is called a human–animal hybrid.
Patient derived xenografts are created by xenotransplantation of human tumor cells into immunocompromised mice, and is a research technique frequently used in pre-clinical oncology research.
Excerpted from Wikipedia’s “xenotransplantation” article, available under the CC BY-SA 4.0 licence.