XIAP

Also known as MIHA, API3, BIRC4, IAP-3, ILP1, XLP2, hIAP-3, hIAP3

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.

Gene data

XIAP

Name: X-linked inhibitor of apoptosis
Type: protein-coding
Chromosome: X
Position: 123,859,693–123,913,972 (+)
Aliases: API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Ensembl: ENSG00000101966
RefSeq RNA: NM_001167.4, NM_001204401.2, NM_001378590.1, NM_001378591.1, NM_001378592.1
RefSeq protein: NP_001158.2, NP_001191330.1, NP_001365519.1, NP_001365520.1, NP_001365521.1

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011].

Gene Ontology

Biological process

DNA damage response negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway regulation of BMP signaling pathway positive regulation of protein ubiquitination positive regulation of protein ubiquitination positive regulation of protein ubiquitination positive regulation of type I interferon production

Molecular function

ubiquitin-protein transferase activity ubiquitin-protein transferase activity ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity protein binding identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm nucleolus cytoplasm cytoplasm

Pathways

NF-kappa B signaling pathway - Homo sapiens (human)Ubiquitin mediated proteolysis - Homo sapiens (human)Apoptosis - Homo sapiens (human)Apoptosis - multiple species - Homo sapiens (human)Necroptosis - Homo sapiens (human)Focal adhesion - Homo sapiens (human)NOD-like receptor signaling pathway - Homo sapiens (human)Toxoplasmosis - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)

via MyGene.info

Wikidata facts

Image: Protein BIRC4 PDB 1c9q.png

Show 5 more facts

HomoloGene ID: 901
genomic end: 123047829
exact match: identifiers.org/ncbigene/331
genomic start: 122993574
cytogenetic location: Xq25

Sources (7)

via Wikidata · CC0

~5 min read

Article

9 sections

Contents

Discovery
Structure
Function
Inhibiting XIAP
Clinical significance
Interactions
References
Further reading
External links

XIAP is a member of the inhibitor of apoptosis family of proteins (IAP). IAPs were initially identified in baculoviruses, but XIAP is one of the homologous proteins found in mammals. It is so called because it was first discovered by a 273 base pair site on the X chromosome. The protein is also called human IAP-like Protein (hILP), because it is not as well conserved as the human IAPS: hIAP-1 and hIAP-2. XIAP is the most potent human IAP protein currently identified.