FASLG
Sign in to saveAlso known as ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6
protein-coding gene in the species Homo sapiens
Gene data
FASLG- Name
- Fas ligand
- Type
- protein-coding
- Position
- 172,659,102–172,666,876 (+)
- Aliases
- ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A
- Ensembl
- ENSG00000117560
- RefSeq RNA
- NM_000639.3, NM_001302746.2
- RefSeq protein
- NP_000630.1, NP_001289675.1
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Fas ligand
- Symbol
- FASLG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:172,658,990-172,666,891
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 533
- exact match
- identifiers.org/ncbigene/356
- genomic end
- 172666876
- genomic start
- 172659103
- cytogenetic location
- 1q24.3
- Commons category
- Fas ligand
via Wikidata · CC0