Also known as 2700049M22Rik, AI875481, AU022477, FP497, BH3 interacting domain death agonist
protein-coding gene in the species Homo sapiens
Gene data
BID- Name
- BH3 interacting domain death agonist
- Type
- protein-coding
- Position
- 17,734,138–17,774,770 (−)
- Aliases
- FP497
- Ensembl
- ENSG00000015475
- RefSeq RNA
- NM_001196.4, NM_001244567.2, NM_001244569.2, NM_001244570.2, NM_001244572.2
- RefSeq protein
- NP_001187.1, NP_001231496.1, NP_001231498.1, NP_001231499.1, NP_001231501.1
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
BH3 interacting domain death agonist
- Symbol
- BID
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:17,734,138-17,774,770
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI