TRADD
Sign in to saveAlso known as Hs.89862, TNFRSF1A associated via death domain
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.
Gene data
TRADD- Name
- TNFRSF1A associated via death domain
- Type
- protein-coding
- Position
- 67,153,969–67,163,760 (−)
- Aliases
- Hs.89862
- Ensembl
- ENSG00000102871
- RefSeq RNA
- NM_001323552.2, NM_003789.4, NM_153425.1
- RefSeq protein
- NP_001310481.1, NP_003780.1
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TNFRSF1A associated via death domain
- Symbol
- TRADD
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:67,153,969-67,163,760
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.
TRADD is an adaptor protein.
Excerpted from Wikipedia’s “TRADD” article, available under the CC BY-SA 4.0 licence.