ZCCHC8

Name

zinc finger CCHC-type containing 8

Type

protein-coding

Position

122,471,600–122,500,932 (−)

Aliases

PFBMFT5

Ensembl

ENSG00000033030

RefSeq RNA

NM_001350935.2, NM_001350936.2, NM_001350937.2, NM_001350938.2, NM_017612.5

RefSeq protein

NP_001337864.1, NP_001337865.1, NP_001337866.1, NP_001337867.1, NP_060082.2

This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017].

via MyGene.info

Wikidata facts

via Wikidata · CC0