ZEB1

Also known as zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

Gene data

ZEB1

Name: zinc finger E-box binding homeobox 1
Type: protein-coding
Position: 31,318,495–31,529,814 (+)
Aliases: AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Ensembl: ENSG00000148516
RefSeq RNA: NM_001128128.3, NM_001174093.2, NM_001174094.2, NM_001174095.2, NM_001174096.2
RefSeq protein: NP_001121600.1, NP_001167564.1, NP_001167565.1, NP_001167566.1, NP_001167567.1

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II central nervous system development negative regulation of endothelial cell differentiation positive regulation of neuron differentiation

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding chromatin binding DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm nucleolus

Pathways

Transcriptional misregulation in cancer - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Prostate cancer - Homo sapiens (human)Developmental Biology Cytokine Signaling in Immune system Cell-Cell communication Immune System Adherens junctions interactions Cell-cell junction organization Cell junction organization

via MyGene.info

Wikidata facts

Image: Protein ZEB1 PDB 2e19.png

Show 5 more facts

HomoloGene ID: 31779
exact match: identifiers.org/ncbigene/6935
genomic end: 31818742
genomic start: 31607424
cytogenetic location: 10p11.22

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Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has seven zinc fingers and one homeodomain. The structure of the homeodomain is shown on the right.