ZFHX3

Name

zinc finger homeobox 3

Type

protein-coding

Position

72,782,885–73,891,871 (−)

Aliases

ATBF1, ATBT, ATFB8, C16orf47, EIG20, SCA4, ZFH-3, ZNF927

Ensembl

ENSG00000140836

RefSeq RNA

NM_001164766.2, NM_001386735.1, NM_006885.4, NR_163978.1, XM_017023251.3

RefSeq protein

NP_001158238.1, NP_001373664.1, NP_008816.3, XP_016878740.1, XP_024306059.1

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

via MyGene.info

Gene · Ensembl

zinc finger homeobox 3

Symbol

ZFHX3

Biotype

Protein coding

Organism

Homo sapiens

Location

16:72,782,885-73,891,871

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein ATBF1 PDB 2da1.png

via Wikidata · CC0