ZNF703
Sign in to saveAlso known as ZEPPO1, ZNF503L, ZPO1, NLZ1, zinc finger protein 703
ZNF703 is a gene which has been linked with the development of breast cancers. ZNF703 is contained within the NET/N1z family responsible for regulation of transcription essential for developmental growth especially in the hindbrain. Normal functions performed by ZNF703 include adhesion, movement and proliferation of cells. ZNF703 directly accumulates histone deacetylases at gene promoter regions but does not bind to functional DNA.
Gene data
ZNF703- Name
- zinc finger protein 703
- Type
- protein-coding
- Position
- 37,695,782–37,700,019 (+)
- Aliases
- NLZ1, ZEPPO1, ZNF503L, ZPO1
- Ensembl
- ENSG00000183779
- RefSeq RNA
- NM_025069.3
- RefSeq protein
- NP_079345.1
Predicted to enable DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to estradiol stimulus; mammary gland epithelial cell differentiation; and positive regulation of mammary gland epithelial cell proliferation. Located in cytoplasm and nuclear matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 81391
- exact match
- identifiers.org/ncbigene/80139
- genomic end
- 37700019
- genomic start
- 37695782
- cytogenetic location
- 8p11.23
Sources (4)
via Wikidata · CC0
~4 min read
Article
6 sectionsContents
- Discovery
- Location
- Role in cancer
- Prognosis
- Resistance to drugs
- References
ZNF703 is a gene which has been linked with the development of breast cancers. ZNF703 is contained within the NET/N1z family responsible for regulation of transcription essential for developmental growth especially in the hindbrain. Normal functions performed by ZNF703 include adhesion, movement and proliferation of cells. ZNF703 directly accumulates histone deacetylases at gene promoter regions but does not bind to functional DNA.
Following research by scientists at Cancer Research UK, it was the first oncogene discovery in the past six years.