zucapsaicin
Sign in to saveAlso known as Civamide, (Z)-Capsaicin, cis-Capsaicin
Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. Zucapsaicin is a member of phenols and a member of methoxybenzenes. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1 that reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).
~8 min read
Encyclopedic overview
12 sectionsContents
- Pharmacology
- Pharmacodynamics
- Mechanism of action
- Pharmacokinetics
- Absorption
- Metabolism
- Route of elimination
- Half life
- Toxicity
- Chemical and Physical Properties
- Computed properties
- References
Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. Zucapsaicin is a member of phenols and a member of methoxybenzenes. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1 that reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).
Zucapsaicin has been tested for treatment of a variety of conditions associated with ongoing nerve pain. This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis. It was approved by the Health Canada in 2010 as topical cream sold under the brand name Zuacta. It has a melting point of 71.5–74.5 °C.
Excerpted from Wikipedia’s “zucapsaicin” article, available under the CC BY-SA 4.0 licence.