Anti-aging substances

thumb|class=skin-invert-image|Structure of the antioxidant glutathione

peptide hormones that stimulate growth, cell reproduction, and cell regeneration

Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, and is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotic medication. It has been shown to inhibit inflammation, and is not associated with weight gain. Metformin is taken by mouth.

coenzyme NAD in any of its oxidation states

human hormone

thumb|Telomerase catalytic subunit TERT of [[Tribolium castaneum (Red flour beetle), bound to putative RNA template and telomeric DNA (PDB 3KYL)]] thumb|A conceptual diagram showing the protein component of telomerase (TERT) in grey and the RNA component (TR) in yellow

pair of enantiomers

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to interleukin-2 (IL-2), inhibiting their activity.

field of lengthening human lifespan by means such as tissue rejuvenation or gene therapy

Carnosine (beta-alanyl-L-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. Carnosine was discovered by Russian chemist Vladimir Gulevich.

p38 mitogen-activated protein kinases

chemical compound

Acetyl-L-carnitine (ALCAR or ALC), also known as levacecarnine, is an acetylated form of L-carnitine. It is naturally produced by the human body, and it is available as a dietary supplement. Acetylcarnitine is broken down in the blood by plasma esterases to carnitine which is used by the body to transport fatty acids into the mitochondria for breakdown and energy production.

skin care product

chemical compound

A senolytic (from the words senescence and -lytic, "decomposition or breakdown") is among a class of small molecules under basic research to determine if they can selectively induce death of senescent cells and improve health in humans. A goal of this research is to discover or develop agents to delay, prevent, alleviate, or reverse age-related diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging.

protein-coding gene in the species Homo sapiens

medicine that stimulates red blood cell production

A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals. Some possible geroprotectors include melatonin, carnosine, metformin, rapamycin, nicotinamide mononucleotide (NMN), delta sleep-inducing peptide,glycine, and psilocin.

chemical compound

SRT-1720 is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and efficacy in humans have not been established.

thumb|250px|Original presentation of Gerovital Gerovital H3 (or procaine hydrochloride and products known as GH3 and other variants, which may or may not be identical to Gerovital H3) is a preparation developed during the 1950s and promoted by its advocates as an effective anti-aging treatment. In the United States, the FDA bans Gerovital H3 from interstate commerce as an unapproved drug and, since 1982, has prohibited its importation.

(–)-Benzofuranylpropylaminopentane (BPAP; developmental code name FPFS-1169) is an experimental drug related to selegiline which acts as a monoaminergic activity enhancer (MAE). It is orally active in animals.

class of enzymes